Arginine vasopressin potentiates methyldopa induced hypotension in anesthetized Wistar rats.
نویسندگان
چکیده
Albino Wistar rats (either sex, 225 to 250 g) were anesthetized with Sodium pentobarbitone (50 mg/kg, i.p.). Blood pressure was measured with a pressure transducer (T301) on a INCO polygraph through a polypropylene cannula placed in the carotid artery. A polypropylene cannula introduced in the jugulat vein was used for the infusion of drugs. In this study we have tried to ascertain the effect of AVP on the hypotensive action of methyldopa in anesthetized Wistar rats.
منابع مشابه
Hypotensive and bradycardic effects of centrally administered vasopressin in stroke-prone spontaneously hypertensive rats.
The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 microliter/hr) for 21 hours, and blood pressure and heart rate were monitored. Arginine vasopressin caused transient hypertension ...
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ورودعنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 37 2 شماره
صفحات -
تاریخ انتشار 1993